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KMID : 0379520060220030267
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한국독성학회지
2006 Volume.22 No. 3 p.267 ~ p.273
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Tungtungmadic Acid Isolated from Salicornia herbacea Suppresses the Progress of Carbon Tetrachloride-induced Hepatic Fibrosis in Mice
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Chung Young-Chul
Jeong Hye-Gwang
Choi Jae-Ho
Oh Kyo-Nyeo
Chun Hyo-Kon
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Abstract
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Tungtungmadic acid(3-caffeoyl, 4-dihydrocaffeoyl quinic acid: CDCQ) is a new chlorogenic acid derivative isolated from the Salicornia herbacea. The suppressive effects of CDCQ on the progress of acute carbon tetrachloride(CCl_4)-induced hepatic fibrosis were investigated in mice. CDCQ significantly suppressed CCl_4-induced hepatic necrosis and inflammation, as determined by serum enzymatic activities of alanine and aspartate aminotransferase and serum TNF-alpha levels in a dose-dependent manner. In addition, increased hepatic lipid peroxidation and fibrosis after acute CCl_4 treatment were suppressed by the administration of CDCQ. CDCQ also significantly prevented the elevation of hepatic hydroxyproline and collagen content and {alpha}-smooth muscle actin({alpha}-SMA) expression in the liver of CCl_4-intoxicated mice. These results suggest that the suppressive effects of CDCQ against the acute CCl_4-induced hepatic fibrosis possibly related to its ability to block both hepatic inflammation and the activation of hepatic stellate cells.
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KEYWORD
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Tungtungmadic acid, Carbon tetrachloride, Hepatic fibrosis, Collagen, Inflammation
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